Lair-1 Mouse Anti-Human, Alexa Fluor 647, Clone: Dx26, Bd, Mouse Monoclonal Antibody, Each

Details:

The dx26 monoclonal antibody specifically binds to leukocyte-associated immunoglobulin-like receptor 1 (lair-1/ hlair1/leukocyte-associated ig-like receptor 1) that is encoded by lair1, and also known as, cd305. Lair-1 is a ∽32 kda type i transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory (itim) motifs. Lair-1 is expressed on t cells, b cells, nk cells, monocytes, and dendritic cells. Lair-1 recruits shp-1 and shp-2 tyrosine phosphatases upon activation. Crosslinking of the lair-1 expressed on t cells or nk cells can result in strong inhibition of cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, lair-1 does not appear to recognize mhc class i molecules and thus represents a novel mhc class i-independent mechanism of nk cell regulation.