Lamin A/C Mouse, Unlabeled, Clone: 14, Bd, Mouse Monoclonal Antibody, Each

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The nuclear envelope (ne) is a specialized extension of the er that contains numerous pore complexes interconnected with the nuclear lamina. The nuclear lamina composes the structural framework for the ne and serves as a chromatin anchor site, thus playing a major role in interphase nuclear organization. The major component of nuclear lamina are intermediate filament-like proteins called lamins. In mammalian somatic cells, there are three major lamins, a, b1, and c, and two minor lamins, b2 and a10. A-type lamins (a, a10, and c) are encoded by a single gene and are produced by alternative splicing, while b-type lamins (b1 and b2) are encoded by separate genes. B-type lamins are found in all nucleated somatic cells, while the expression of a-type lamins are developmentally regulated. Mice lacking lamin a show no overt abnormalities until postnatal development when perturbations in nuclear envelop structure correlate with the appearance of muscular dystrophy. In addition, lamin a is mutated in lipodystrophy, a disorder characterized by reduction in subcutaneous adipose tissue. Thus, lamin a and c may be important for nuclear envelope formation during postnatal cell differentiation.Immunofluorescence, western blotting