Muc-1 Ab-5 Hamster Monoclonal Antibody, Muc-1 Ab-5, Hamster Monoclonal Antibody Provides Accurate, Reproducible Results, Each

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Muc1 is a heavily o-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kda) and a smaller subunit (14-28kda) noncovalently associated with each other. Transgenic muc1 has been shown to associate with all four erbb receptors and localize with erbb1 (egfr) in lactating glands1. Muc1 can act as a ligand for icam-1 on huvec cells; it can bind beta-catenin, gsk3beta and it associates with grb2-sos upon phosphorylation. Host species: hamsterclone: mh1 (ct2)isotype: iggspecies reactivity: human and mouse. Others not tested.Epitope: aa 239-255immunogen: a synthetic peptide corresponding to aa 239-255 (sslsytnpavaatsanl) from the cytoplasmic tail of muc-1molecular weight: 14-28kdapositive control: mcf-7 cells; breast cacellular localization: cytoplasmic and membrane recommended for:immunohistochemistry (formalin/paraffin)western blottingimmunofluorescenceimmunoprecipitationflow cytometry note:usa: ruo; int'l: ruo