Munc-18 Mouse, Unlabeled, Clone: 31, Bd, Mouse Monoclonal Antibody, Each

Details:

There are two munc-18 isoforms: munc-18-1 and munc-18-2. Munc-18-1 (n-sec1 or rb-sec1; 68 kda) is a neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis. Munc-18-2 exhibits 63% amino acid sequence identity with munc-18-1. Although munc-18-2 is expressed in most tissues, munc-18-1 is primarily expressed in brain. Both forms of munc-18 bind tightly to syntaxins 1a, 2, and 3, but not to syntaxin 4. Syntaxin 1a is a plasma membrane protein implicated in synaptic vesicle docking. Following calcium entry into the presynaptic nerve terminal, the neurotransmitter-containing synaptic vesicle fuses with the plasma membrane at a region known as the active zone. Thus, by virtue of its interaction with syntaxin 1a, munc-18-1 is thought to have an essential function in neurotransmitter release.