N-Cadherin Mouse, Unlabeled, Clone: 32, Bd, Mouse Monoclonal Antibody, Each

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Cadherins are a family of ca2+;-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (α, β, γ). Members of the cadherin family include p-cadherin, e-cadherin (uvomorulin), n-cadherin (neural cadherin), r-cadherin, cadherin 5, l-cam, and ep-cadherin. N-cadherin mrna is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mrna expression, cytokine modulation, and protease-mediated turnover modulate n-cadherin protein levels during development. In addition, n-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of β-catenin complexed with n-cadherin results in dissociation of n-cadherin from actin. However, n-cadherin also interacts with a ptp1b-like phosphatase that dephosphorylates β-catenin and promotes n-cadherin/actin association. Thus, n-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.Immunofluorescence, western blotting