Nanog Mouse Anti-Mouse, Alexa Fluor 488, Clone: M55-312, Bd, Mouse Monoclonal Antibody, Each

Details:

The m55-312 monoclonal antibody reacts with mouse nanog (named for tir na nog, the land of the ever-young of celtic mythology), which is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors lif (leukemia inhibitory factor) and bmp (bone morphogenic protein). When nanog expression is down-regulated, cell differentiation can proceed. Proteins that regulate nanog expression include transcription factors oct4, sox2, foxd3, and tcf3 and tumor suppressor p53.