Nat1 Mouse, Unlabeled, Clone: 35, Bd, Mouse Monoclonal Antibody, Each

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Eif-4 proteins are required for recognition of mrna and acceleration of protein translation. This group of proteins consists of the rna helicase eif-4a, the rna-binding protein eif-4b, the cap-binding protein eif-4e, and eif-4g (p220). Nat1 (novel apobec-1 target no. 1), Also known as dap-5 (death associated protein -5), is homologous to eif-4g. Amino acid sequence comparison of nat1 and eif-4 shows that nat1 lacks an eif-4g n-terminal region. This region mediates eif-4g association with eif-4e. The highest degree of homology is within the central portions of nat1 and eif-4g, while the lowest degree of homology occurs at the c-terminus. Nat1 more closely resembles a cleaved form of eif-4g that is involved in cap-independent translation. It is thought that nat1 is involved in the repression of translation via its inhibition of both cap-dependent and cap-independent translation.Immunofluorescence, immunoprecipitation, western blotting