Nek2 Mouse Anti-Human, Unlabeled, Clone: 20, Bd, Mouse Monoclonal Antibody, Each

Details:

Reversible protein phosphorylation is critical for progression through the cell cycle and mitosis. In aspergillus nidulans, the nima gene (never itosis) encodes a protein kinase that is essential for mitosis. Three human genes (nek1, 2, and 3 [nima-related kinase]) with significant homology to the a. Nidulans nima have been reported. The nek2 gene encodes a protein of 445 amino acids and, like its fungal homolog, its expression is regulated throughout the cell cycle. In hela cells, nek2 activity and expression are low during m and g1 phases of the cell cycle. However, both parameters increase during s phase and mitosis. In addition, nek2 phosphorylates protein substrates exclusively at serine and threonine residues. Thus, like its fungal homolog, nek2 may be a crucial element in controlling the cell's entry into s phase and mitosis.This antibody is routinely tested by western blot analysis. Other applications were tested at bd biosciences pharmingen during antibody development only or reported in the literature.