150 [Glued] Mouse, Unlabeled, Clone: 12, Bd, Mouse Monoclonal Antibody, Each

Details:

150 [Glued] was identified as a polypeptide associated with cytoplasmic dynein,the minus-end-directed microtubule-based motor protein. P150 [glued] is also a member of the oligomeric dynactin complex. Dynactin mediates dynein-driven vesicle motility, as well as lower eukaryote nuclear transport. P150 [glued] bears significant homology to the product of the glued gene in drosophila. It has been shown in vitro to be a required activator of dynein-mediated transport along microtubules. The p150 [glued] component of the dynactin complex binds to microtubules and the actin-like protein centractin (arp-1), another member of the dynactin complex. In the developing rat, p150 [glued] is expressed at high levels in neural tissue. Microtubule binding assays with selected constructs of p150 [glued] indicate that amino acids 39-150 are required for microtubule association.Immunofluorescence, western blotting