230 Trans Golgi Mouse Anti-Human, Unlabeled, Clone: 15, Bd, Mouse Monoclonal Antibody, Each

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The golgi apparatus is a very complex and dynamic organelle that functions in protein sorting and modification. Numerous structural and regulatory proteins are involved in the budding, docking, and fusion of golgi-directed vesicles. P230 trans golgi is a peripheral membrane protein associated with the cytosolic face of the trans golgi network (tgn). Protein sequence analysis indicates that it is highly hydrophilic and contains two proline-rich regions, as well as a high frequency of heptad repeats which are characteristic of α-helices that form dimeric coiled-coiled structures. Additionally, p230 trans golgi contains a eslaleelel sequence, a motif of the acidic granin proteins that are found in secretory granules of neuroendocrine cells. P230 trans golgi cycles between the cytosol and the tgn via non-clathrin coated vesicles in a g protein-dependent manner. The localization of p230 trans golgi to the tgn is dependent on aromatic residues in its c-terminal non-coiled coil domain. Thus, p230 trans-golgi is atgn-specific protein that is important for the biogenesis of distinct populations of non-clathrin coated vesicles and, thus, functions in vesicular transport from the tgn.Host species: mouseclone: 15isotype: igg1species reactivity: humanimmunogen: human p230 trans golgi aa. 2063-2179Formula weight [chemical]: 230kdaimmunofluorescence, western blotting