54nrb Mouse, Unlabeled, Clone: 3, Bd, Mouse Monoclonal Antibody, Each

Details:

Splicing, the removal of introns from pre-mrna, is mediated by spliceosomal complexes that contain multiple snrnps and a number of non-snrnp splicing factors, such as hprp17 and hprp18. P54 [nrb] ( n uclear r na- b inding kda) is a non-snrnp rna splicing factor. It binds and enhances the activity of topoisomerase i, the enzyme that nicks dna to relieve torsional stress during replication and transcription. P54 [nrb] is the the human homolog of mouse nono and bovine ipeb. The n-terminal half of p54 [nrb] contains two rna recognition motifs (rrms), that allow it to bind single stranded rna. These motifs are included in a region that is 71% homologous with the human splicing factor psf and 42% homologous with the drosophila puff-specific protein bj6. In addition to its role in rna splicing, p54 [nrb] functions as a dna transcription factor in multiple cell types. The n-terminal portion of p54 [nrb] also mediates its interaction with dna. The ability of p54 [nrb] to bind dna, but not rna, is thought to require post-translational modification. Thus, p54 [nrb] can function as either an rna splicing factor or a dna transcription factor in a post-translational-dependent manner.