70 [S6k] Mouse, Unlabeled, Clone: 16, Bd, Mouse Monoclonal Antibody, Each

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Increased protein synthesis, an obligatory step in cell proliferation, is regulated by the phosphorylation of a number of translational components, such as ribosomal protein s6. P70 s6 kinase (p70 [s6k]), a cytosolic kinase that is primarily responsible for s6 phosphorylation, belongs to a family of at least six s6 kinases. P70 [s6k] and p85 [s6k] are two isoforms of the same kinase. Although they are encoded by the same gene, p80 [s6k] contains a 23 amino acid n-terminal extension that serves as a nuclear localization sequence. These kinases are located in a p21 ras-independent signaling pathway and are regulated by ser/thr phosphorylation in response to mitogenic stimulation. Activation of p70 [s6k] requires sequential phosphorylations within the autoinhibitory domain and at thr 389. P70 [s6k] associates with pdk-1 and pkc? To form a possible pi3-k signaling complex. The immunosuppressive agent rapamycin forms an intracellular complex with fkbp12 and frap (raft1) that inhibits phosphorylation of p70 [s6k] at thr 389 and, in turn, prevents enzyme activation. Thus, p70 [s6k] is an important regulator of cell proliferation and a potential target of agents that modify the immune and proliferative responses. P70 [s6k] has been reported to be observable migrating within a range of 60-70 kd by western blotting.Host species: mouseclone: 16isotype: igg1species reactivity: ratimmunogen: rat p70 [s6k] aa. 2-121Formula weight [chemical]: 60-70kdaimmunofluorescence, western blotting