Pai-1 Mouse, Unlabeled, Clone: 41, Bd, Mouse Monoclonal Antibody, Each

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Fibrinolysis is regulated by the plasminogen activators, tissue plasminogen activator (tpa) and urokinase pa (upa), and by the plasminogen activator-inhibitors (pais). Two pais include the serpin family members, pai-1 and pai-2. Pai-1 is a glycoprotein found in plasma, platelets, endothelial cells, hepatoma cells, and fibrosarcoma cells. Thrombin, endotoxin, and il-1 induce pai-1 synthesis in endothelial cells, which is where the major portion of plasma pai-1 is produced. Pai-2 is a glycoprotein expressed in placenta and monocyte macrophages. The upa/plasmin system may play a key role in cancer progression through degradation of the extracellular matrix during tumor cell migration. Paradoxically, high levels of pai-1 are also predictive of poor prognosis of cancer patients. This finding may be a result of the role of plasmin proteolysis in the prevention of tumor vessel assembly. Pai-1 can promote tumor angiogenesis, and the mechanism may involve pai-induced regulation of plasmin proteolysis during tumor angiogenesis. Thus, pai-1 is a serpin protease inhibitor that is important for the regulation of plasmin proteolysis during fibrinolysis and extracellular matrix degradation.Host species: mouseclone: 41isotype: igg1species reactivity [for features main]: humanimmunogen: human pai-1 aa. 207-329Immunofluorescence, western blotting