Pax-5 Mouse, Unlabeled, Clone: 24, Bd, Mouse Monoclonal Antibody, Each

Details:

There are at least nine members of the paired box (pax) gene family whose protein products are transcription factors involved in development. The conserved paired box dna-binding domain is found in the n-terminal region of pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The ser/thr/pro-rich region in the c-terminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied pax family members, pax 5, is a b cell specific activator protein (bsap). In the early stages of b cell development, pax-5 influences the expression of several b-cell-specific genes, such as cd19 and cd20. Pax-5 is expressed primarily in pro-, pre-, and mature b cells, but not in plasma cells. Interestingly, pax-5 mrna is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of b lymphopoiesis. Pax-5 has been found to be important in both b cell and nervous system development.Immunofluorescence, immunoprecipitation, western blotting