Paxillin Mouse, Unlabeled, Clone: 177, Bd, Mouse Monoclonal Antibody, Each

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Paxillin, a focal adhesion protein, is a substrate for several tyrosine kinases such as src, fak, and p120brc/abl. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. This is consisent with the possibility that paxillin is involved in the regulation of cell morphology. Additionally, because of its sh3-binding domain, paxillin associates tightly with fak and crk in an extracellular matrix-independent manner. Although paxillin was initially detected in fibroblasts, its phosphorylation may be important during neurite extension during differentiation.