Pi3-Kinase Mouse, Unlabeled, Clone: 4, Bd, Mouse Monoclonal Antibody, Each

Details:

Pi3-kinase phosphorylates the d-3 position of the inositol ring of phosphatidylinositol (ptdins), ptdins(4)p and ptdins(4,5)p2 to produce the respective pi3-phosphorylated derivatives. Pi3-kinase exists as a heterodimer of 85 kda (p85) and 110 kda (p110) subunits. The p85 subunit contains two sh2 domains and an sh3 domain. It associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. P85 may serve as regulator of the catalytic subunit, p110, by acting as the link between pi3-kinase and the ligand-activated receptor. Two distinct forms of the p85 subunit have been described: 1) p85 α; , which binds tightly to the catalytic subunit, and 2) p85ß, a protein whose function is presently unknown. Both isoforms bind to activated receptors and serve as tyrosine kinase substrates.