Pi3-Kinase P110Α Mouse, Unlabeled, Clone: 19, Bd, Mouse Monoclonal Antibody, Each

Details:

Phosphatidylinositol 3 (pi3) -kinase participates in insulin-stimulated glucose uptake, pdgf-induced membrane ruffling, and g-protein receptor signaling. It exists as a heterodimer of 85kda (p85) and 110kda (p110) subunits. The p85 subunit associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. P85 regulates the p110 catalytic subunit by acting as the link between pi3-kinase and the ligand-activated receptor. Four isoforms of p110 have been identified (α, β, γ, and δ). The p110α isoform contains an n-terminal region involved in p85 binding and a c-terminal kinase domain. P85/p110α-type pi kinase phosphorylates the d-3 and d-4 position of the inositol ring of pi, thereby producing ptdins(3)p, ptdins(3,4)p[2], ptdins(3,4,5)p[3], ptdins(4)p, and ptdins(4,5) p[2]. During induction of chemotaxis by the chemokine sdf-1α, pi3-kinase regulates adhesion and erm protein redistribution in the lymphocyte plasma membrane. In addition, pi3-kinases activate other signaling molecules, such as p70 s6 kinase and akt/protein kinase b. Thus, p85/p110α-type pi kinase is a ubiquitously expressed kinase that is involved in a variety of cell signaling cascades.Host species: mouseclone: 19isotype: igg1species reactivity: humanimmunogen: human pi3-kinase p110α aa. 101-300Formula weight [chemical]: 110kdaimmunofluorescence, western blotting