Pka[C] Mouse, Unlabeled, Clone: 5b, Bd, Mouse Monoclonal Antibody, Each

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Camp-dependent protein kinase (pka) is composed of two distinct subunits: catalytic (c) and regulatory (r). Four regulatory subunits have been identified: riα, riβ, riiα, and riiβ. These subunits define type i and ii camp-dependent protein kinases. Following binding of camp, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type i and type ii holoenzymes have three potential c subunits (cα, cβ, or cγ). Type ii pka can be distinguished by autophosphorylation of the r-subunits, while type i pka binds mg/atp with high affinity. The levels of expression of the different subunits vary according to cell and tissue type.Immunofluorescence, western blotting