Psen1 Rabbit Anti-Human, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Psen1, Each

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Alzheimer's disease (ad) patients with an inherited form of the disease carry mutations in the presenilin proteins (psen1; psen2) or in the amyloid precursor protein (app). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in ad brains). Presenilins are postulated to regulate app processing through their effects on gamma-secretase, an enzyme that cleaves app. Also, it is thought that the presenilins are involved in the cleavage of the notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [Provided by refseq