Rad17 Rabbit Anti-Human, Mouse, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Rad17, Each

Details:

The protein encoded by this gene is highly similar to the gene product of schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and dna damage repair in response to dna damage. This protein shares strong similarity with dna replication factor c (rfc), and can form a complex with rfcs. This protein binds to chromatin prior to dna damage and is phosphorylated by the checkpoint kinase atr following damage. This protein recruits the rad1-rad9-hus1 checkpoint protein complex onto chromatin after dna damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the dna-damage-induced cell cycle g2 arrest, and is thought to be a critical early event during checkpoint signaling in dna-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [Provided by refseq