Rat Anti-Aminopeptidase N/Cd13, Clone: Sl13,, Rat Monoclonal Antibody, Each

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Specifically detects Aminopeptidase N/CD13 clone: SL13 in Mouse samples, and it is validated for Activity Assay, Immunocytochemistry, Immunohistochemistry (Paraffin)Aminopeptidase N (APN), also known as CD13 or Alanyl Aminopeptidase, is the protein product of the ANPEP gene. APN is a membrane-bound zinc metalloproteinase that catalyzes the cleavage of N-terminal amino acids and is involved in several biological processes including antigen processing and presentation, cell adhesion, tumor invasion and metastasis, neurotransmitter degradation. Widely expressed in many tissues and cells, including kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS, as well as in endometrial stromal cells, but not in the endometrial glandular cells. It is also found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. An elevation of the soluble form is found to be elevated in plasma and effusions of cancer patients. Elevated APN level in urine is also used in the diagnosis of kidney damages, such as that resulted from graft rejection after renal transplantation. APN is also known as a receptor for human coronavirus.