Rfx5, Rabbit, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Rfx5, Each

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A lack of mhc-ii expression results in a severe immunodeficiency syndrome called mhc-ii deficiency, or the bare lymphocyte syndrome (bls; mim 209920). At least 4 complementation groups have been identified in b-cell lines established from patients with bls. The molecular defects in complementation groups b, c, and d all lead to a deficiency in rfx, a nuclear protein complex that binds to the x box of mhc-ii promoters. The lack of rfx binding activity in complementation group c results from mutations in the rfx5 gene encoding the 75kda subunit of rfx (steimle et al., 1995). Rfx5 is the fifth member of the growing family of dna-binding proteins sharing a novel and highly characteristic dna-binding domain called the rfx motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [Provided by refseq