Rock-Ii Mouse, Unlabeled, Clone: 21, Bd, Mouse Monoclonal Antibody, Each

Details:

Activity of the gtp-binding proteins is regulated by gaps, that accelerate binding, and gtpases, that enhance the rate of gtp hydrolysis (ras, rho, cdc42hs, and rac). The isoforms of rho, a small gtp-binding protein, regulate cellular processes such as the formation of the stress fibers, lamelipodia, and filopodia. Rokα (rhoa-binding kinase) is a ser/thr protein kinase that interects with the gtp-binding form of rhoa. Like rhoa, rokα localizes at the cellular margins and colocalizes with acti filaments. The rokα gene encodes a protein of 1302 amino acids with homology to the human myotonic kinase. Although rokα binds to gtp-rhoa, it is not yet clear whether this interaction induces the kinase activity of rokα.Immunofluorescence, immunohistochemistry, immunoprecipitation, western blotting