Serine Racemase Mouse, Unlabeled, Clone: 29, Bd, Mouse Monoclonal Antibody, Each

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The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for n-methyl d-aspartate (nmdar) and 2) non-nmda receptors for ampa and kainate. Nmda receptors require coactivation at both glutamate and glycine sites. D-serine is a d-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on nmda receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5′ phosphate (plp)-dependent enzyme family. Serine racemase mrna is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of d-serine by d-amino acid oxidase attenuates nmda receptor-mediated calcium influx, and implicates d-serine as an endogenouse modulator of nmda receptor function. Thus, glial cell production of d-serine via serine racemase activity may be an important system for modulation of synaptic transmission.Host species: mouseclone: 29isotype: igg1species reactivity [for features main]: mouseimmunogen: mouse serine racemase aa. 127-248Immunofluorescence, western blotting