Siglec-1 (Cd169) Mouse Anti-Human, Pe, Clone: 7-239, Bd, Mouse Monoclonal Antibody, Each

Details:

The 7-239 monoclonal antibody specifically binds to sialic acid-binding ig-like lectin 1 (siglec-1), which is also known as sialoadhesin (sn), or cd169. Siglec-1 is a type i transmembrane glycoprotein that belongs to the siglec family within the ig superfamily. This adhesion molecule especially binds to glycolipids and glycoproteins with terminal α-2 sialyl residues. Siglec-1 is expressed by macrophages and dendritic cells and serves as a cellular interaction molecule. Its expression can be upregulated by cells in response to type ii collagen, or to cytokines including interferons, and tumor necrosis factor. Siglec-1 plays roles in endocytosis, hematopoiesis, and leucocyte migration. It mediates macrophage binding to various cell types including developing and mature leucocytes. Siglec-1 that is expressed by dendritic cells can also bind hiv-1 and may mediate viral transfer to bystander cd4 t cells. Several siglec-1 counter-receptors have been described including cd43, cd206, and cd227 which are expressed by t cells, macrophages, or breast cancer cells, respectively. The 7-239 antibody reportedly blocks siglec-1 functions in some cellular assay systems.