Skp2 Rabbit Anti-Human, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Peptide Of Skp2, Each

Details:

This gene encodes a member of the f-box protein family which is characterized by an approximately 40 amino acid motif, the f-box. The f-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called scfs (skp1-cullin-f-box), which function in phosphorylation-dependent ubiquitination. The f-box proteins are divided into 3 classes: fbws containing wd-40 domains, fbls containing leucine-rich repeats, and fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the fbls class; in addition to an f-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin a-cdk2 s-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1b (cdkn1b, also referred to as p27 or kip1) predominantly in s phase and interacts with s-phase kinase-associated protein 1 (skp1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms. [Provided by refseq]