Snap-25 Mouse, Unlabeled, Clone: 20, Bd, Mouse Monoclonal Antibody, Each

Details:

Release of neurotransmitters from neurons is regulated by exocytosis of synaptic vesicles. This exocytosis is mediated by a complex consisting of membrane components of both the synaptic vesicle and the synaptic plasma membrane. The fusion complex consists of the soluble nsf (n-ethyl-maleimide-sensitive factor) and snaps (soluble nsf attachment proteins), along with the receptor proteins (known as snares) synaptobrevin, synaptotagmin, syntaxin, and snap-25 (synaptosomal-associated protein of 25kda- the name is coincidental to the previously mentioned “snap” terminology). Snap-25 and syntaxin are plasmalemmal proteins (designated as t-snares) while synaptobrevin and synaptotagmin are vesicular proteins (designated as v-snares). These four proteins are thought to constitute an initial snare docking complex for regulated exocytosis. Snap-25 lacks a transmembrane domain, but is linked to the membrane by palmitoylated cysteine residues in the central region of the molecule.Immunofluorescence, immunoprecipitation, western blotting