Stat1 Mouse, Unlabeled, Clone: 1/Stat1, Bd, Mouse Monoclonal Antibody, Each

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Stat (signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated jak family kinases and subsequent recruitment/activation of stat proteins by tyrosine phosphorylation. Active stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and stat2 are components of the isgf3 (interferon-stimulated gene factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91kda stat1α and 84kda stat1β; stat1α has 38 additional c-terminal amino acids. In response to the binding of ifnα, ifnγ, egf, pdgf, or csf-1 to their respective receptors, the stat1 subunits become tyrosine-phosphorylated at y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the dna-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (isgs). Thus, phosphorylation of y701 in stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the isgf3 complex.Host species: mouseclone: 1isotype: igg1species reactivity: humanimmunogen: human stat1 aa. 1-194Formula weight [chemical]: 91/84kdaimmunofluorescence, immunohistochemistry, immunoprecipitation, western blotting