$ 492.75
Details:
Stats (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including interleukins (il) 2-5, il-7, il-15, gm-csf, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated jak family kinases and subsequent recruitment/activation of stats by tyrosine phosphorylation. Active stats then move to the nucleus to promote transcription of cytokine-inducible genes. Seven stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of t helper type 2 (th2) cells from uncommitted cd4 t cell precursors. Moreover, il-4, secreted by activated t lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of stat6 at tyrosine 641 (y641). The sh3:sh2 domain of stat6 associates with tyrosine-phosphorylated il-4 receptor and the proximal jak kinase phosphorylates stat6 at y641 on the c-terminal side of the sh2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/cbp. While stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.Host species: mouseclone: 23isotype: igg1species reactivity: humanimmunogen: human stat6 c-terminal recombinant proteinformula weight [chemical]: 100kdaimmunofluorescence, western blotting
