Stat6 (Phospho Y641), Rabbit Anti-Human, Mouse, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Synthetic Phosphopeptide Of Stat6, Each

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The protein encoded by this gene is a member of the stat family of transcription factors. In response to cytokines and growth factors, stat family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting il4 mediated biological responses. It is found to induce the expression of bcl2l1/bcl-x(l), which is responsible for the anti-apoptotic activity of il4. Knockout studies in mice suggested the roles of this gene in differentiation of t helper 2 (th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [Provided by refseq