Sulfinate Alkylation Reagent Kit, Each

Details:

The sulfinate alkylation reaction described by prof. Baran is a powerful late stage functionalization tool. Our kit allows to conveniently produce analogues of the lead compound using 6 different sulfinate alkylation reagents. Each vial contains 100 μmol of sulfinate alkylation reagent and a stirring bar to react with 50 μmol of substrate. C-h functionalization will primarily occur on electron-deficient heteroarenes at one or several positions.Standard protocol: several solvents or solvent mixtures can be used to perform the reaction (dmso, dmso/h2o/tfa, chcl3/ h2o/tfa… ). A solution of substrate is made with 300 μmol of substrate in 2.1 Ml selected solvent. 350 μL is added in each vial followed by 20.8 μL of tbuooh (70% in water). The reactions are allowed to stir at 50°c for 12-24 hours.Kit contents: 2 reaction vials of each reagents (100 μmol), 12 reaction vials total.