Tgf Beta-1 Human Elisa Kit, For The Quantitative Detection Of Human Tgf-Beta1, Each

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Tgf beta-1 (tgfb1,transforming growth factor beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines,found almost ubiquitously in tissues. Transforming growth factor (tgf)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of tgf beta-1 requires the binding of av integrin to an rgd sequence in the prodomain and exertion of force on this domain,which is held in the extracellular matrix by latent tgf-b binding proteins. Latent forms are complexes of tgf beta-1,an amino-terminal portion of the tgf-beta precursor,designated tgf-lap (tgf-latency associated peptide),and a specific binding protein,known as ltbp. Tgf beta-1 helps regulates proliferation,differentiation,adhesion,migration in many cell types. Many cells have tgf beta receptors,and the protein positively and negatively regulates many other growth factors. Tgf beta-1 is cleaved into a latency-associated peptide and a mature tgf beta-1 peptide,and is found in either a latent form composed of a tgfb1 homodimer,a lap homodimer,and a latent tgfb1-binding protein,or in an active form composed of a tgf beta-1 homodimer. The mature peptide may also form heterodimers with other tgf beta family members. The gene for tgf beta-1 is frequently upregulated in tumor cells,and mutations in this gene result in camurati-engelmann disease and cystic fibrosis.