Tgf Beta-1 Rat Elisa Kit, For The Quantitative Detection Of Rat Tgf-Beta1, Each

Details:

Tgf beta-1 (tgfb1, transforming growth factor beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (tgf)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of tgf beta-1 requires the binding of av integrin to an rgd sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent tgf-b binding proteins. Latent forms are complexes of tgf beta-1, an amino-terminal portion of the tgf-beta precursor, designated tgf-lap (tgf-latency associated peptide), and a specific binding protein, known as ltbp. Tgf beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have tgf beta receptors, and the protein positively and negatively regulates many other growth factors. Tgf beta-1 is cleaved into a latency-associated peptide and a mature tgf beta-1 peptide, and is found in either a latent form composed of a tgfb1 homodimer, a lap homodimer, and a latent tgfb1-binding protein, or in an active form composed of a tgf beta-1 homodimer. The mature peptide may also form heterodimers with other tgf beta family members. The gene for tgf beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in camurati-engelmann disease and cystic fibrosis.