Cd137 (4-1bb) Ab-1 Mouse Monoclonal Antibody, Cd137 (4-1bb) Ab-1, Mouse Monoclonal Antibody Provides Accurate, Reproducible Results, Each

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4-1Bb (also known as cd137) is an inducible receptor-like protein expressed on the cell surface of activated splenic t cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated t cells. 4-1Bb is structurally related to the members of ngfr/tnfr superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity ngfr, two receptors for tnf (tnfr-i & tnfr-ii), cd30, cd40, ox40, fas, and cd27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1bb include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the c-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine. Host species: mouseclone: bbk-2isotype: igg1/κspecies reactivity: human. Others not known.Epitope: ectodomainimmunogen: ectodomain of human 4-1bb recombinant proteinmolecular weight: 30kdapositive control: spleen, thymus or tonsilcellular localization: membrane recommended for:immunofluorescenceflow cytometry note:usa: ruo; int'l: ruo