57kip2ab-6 Mouse Monoclonal Antibody, Deliver Accurate, Reproducible Results With The P57kip2 Ab-6, Mouse Monoclonal Antibody, Each

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57Kip2 (or cdkn1c) is a potent tight-binding inhibitor of several g1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57kip2 is located on chromosome 11p15.5, A region implicated in both sporadic cancers, wilm's tumor, and beckwith-wiedemann syndrome (bws), a cancer syndrome, making it a tumor suppressor candidate. Bws is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor ii (igf-ii) and h19, both of which seem to be implicated in adrenal neoplasms. Host species: mouseclone: 57p06; same as kp10isotype: igg2b/κspecies reactivity: human and mouse. Others not known.Epitope: not determinedimmunogen: recombinant human p57kip2 proteinmolecular weight: 57kdapositive control: ls174t cells, colon ca or placentacellular localization: nuclear recommended for:immunohistochemistry (formalin/paraffin)western blotting (not suitable)immunoprecipitation (native verified)