Tyrosinase Ab-1 Mouse Monoclonal Antibody, Provide Accurate, Reproducible Results With The Tyrosinase Ab-1, Mouse Monoclonal Antibody, Each

Details:

Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to l-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic t-cell recognition in melanoma patients. Host species: mouseclone: t311isotype: igg2aspecies reactivity: human, dog and cat. Weakly cross-reacts with mouse. Others not known.Epitope: aa 1-433immunogen: recombinant tyrosinase proteinmolecular weight: 70-80kdapositive control: melanoma cell lines and melanomacellular localization: cytoplasmic ab-1 shows no cross-reaction with mage-1 and tyrosinase-related protein 1, trp-1/gp75. Staining of melanomas with ab-1 showed tyrosinase in melanotic as well as amelanotic variants. Ab-1 is a useful marker for melanocytes and melanomas. Occasionally a minor band at 55kda is also detected in western blotting recommended for:immunohistochemistry (formalin/paraffin)western blottingimmunofluorescenceimmunocytology