Tigit Mouse Anti-Mouse, Pe, Clone: 1g9, Bd, Mouse Monoclonal Antibody, Each

Details:

The 1g9 monoclonal antibody specifically binds to t cell immunoreceptor with ig and itim domains (tigit) which is also known as, v-set and transmembrane domain-containing protein 3 (vstm3). Tigit is a 26 kda, type i transmembrane glycoprotein that belongs to the poliovirus receptor (pvr) family. Tigit is expressed on activated and memory cd4 t cells and cd8 t cells, follicular t helper cells, regulatory t cells, and nk cells. Its ligands include the poliovirus receptor (pvr, aka, cd155), poliovirus receptor-related protein 2 (pvrl2, aka, cd112), and poliovirus receptor-related protein 3 (pvrl3, cd113). Tigit functions as a negative regulator of t cell and nk cell responses including proliferation, cytotoxicity, and the production of proinflammatory cytokines. Tigit-deficient mice are reportedly more susceptible to developing autoimmune diseases in certain model systems.