A01, High Affinity Smurf1 Inhibitor; Enhances Bmp Signaling, Each

Details:

A01 is a high affinity smurf1 e3 ubiquitin ligase inhibitor (kd = 3.7 Nm). Attenuates smurf1-mediated smad 1/5 degradation and enhances bmp signaling. Potentiates bmp-2-induced osteoblastic activity in c2c12 myoblasts and mc3t3-e1 osteoblast precursor cells.