A12b4c3, Potent And Selective Polynucleotide Kinase/Phosphatase (Pnkp) Inhibitor, Each

Details:

A12b4c3 is a potent and selective polynucleotide kinase/phosphatase (pnkp) inhibitor (ic50 = 60 nm). Displays no effect on calcineurin, protein pp-1 or aptx. Interrupts dna repair and enhances radiosensitivity of human a549 lung carcinoma and mda-mb-231 cells.