Ac 5216, Selective Tspo Ligand, Each

Details:

Ac 5216 is a ligand of translocator protein (tspo, peripheral benzodiazepine receptor). Exhibits high affinity for tspo in rat whole brain (ki = 0.297 Nm), and high potency against human and rat glial tspo (ic50 values are 2.73 And 3.04 Nm respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.