Aee 788, Potent Egfr And Vegfr Inhibitor, Each

Details:

Aee 788 is a potent egfr and vegfr inhibitor (ic50 values are 2, 6, 59, 77, 160 and 330 nm for egfr, erbb2, vegfr-1, vegfr-2, erbb4 and vegfr-3 respectively). Also inhibits c-abl, c-fms and c-src (ic50 values are 52, 60 and 61 nm respectively). Inhibits proliferation of egfr and erbb2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and vegf-induced angiogenesis in mice. Orally active.