Aliskiren Hemifumarate, Potent Renin Inhibitor; Antihypertensive, Each

Details:

Aliskiren hemifumarate is a potent renin inhibitor (ic50 = 0.6 And 80 nm for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nm). Lowers blood pressure in a hypertensive rodent model. Orally active.