Azd 3988, Potent And Selective Dgat-1 Inhibitor, Each

Details:

Azd 3988 is a potent and selective diacylglycerol acyltransferase (dgat-1) inhibitor (ic50 = 0.6 Nm). Exhibits selectivity for dgat-1 over dgat-2, kv11.1 (Herg) and cytochrome p450 enzymes. Suppresses triacylglyceride (tag) plasma excursion and adipose tissue tag synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.