Azidothymidine, Selective Reverse Transcriptase Inhibitor; Antiretroviral, Each

Details:

Selective reverse transcriptase inhibitor. Exhibits 100-fold selectivity for hiv reverse transcriptase over dna polymerase α. Suppresses hiv-1 replication and enhances cell viability in hiv-1 infected t cells. Attenuates growth of multiple myeloma (mm) cells in vitro and reduces growth of mm tumor xenografts in mice. Increases differentiation ipscs into cortical neurons and reduces the over-proliferation of neural precursors. Orally bioavailable and brain penetrant. Antiretroviral agent. Also decreases crispr-mediated homology directed repair (hdr) efficiency.