Bms 345541, Selective Allosteric Inhibitor Of Ikk; Anti-Inflammatory, Each

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Bms 345541 is a selective allosteric inhibitor of ikk (ic50 values are 0.3 And 4.0 μM for ikkβ and ikkα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates lps-induced cytokine production in vitro and blocks nfκb dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.