Cariporide, Selective Nhe1 Inhibitor; Cardioprotective And Antitumor, Each

Details:

Cariporide is a selective na /h exchanger isoform 1 (nhe1) inhibitor (ic50 values are 0.05, 3 And 1000 μm for nhe1, nhe3 and nhe2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing nhe1. Orally active.