Cladribine, Deoxyadenosine Analog; Pro-Apoptotic, Each

Details:

Cladribine is an adenosine deaminase (ada)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; inhibits cell growth of lymphoid and myeloid neoplasm (ic50 = 20 - 87 nm). Pro-apoptotic; induces dna double-strand breaks. Also inhibits ribonuclease reductase (ic50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.