Crid3 Sodium Salt, Potent Nlrp3 Inflammasome Inhibitor; Inhibits Il-1β Production, Each

Details:

Crid3 sodium salt is a potent nlrp3 inflammasome inhibitor; closes the active conformation of nlrp3 to the inactive state. Directly interacts with the walker b motif within the nlrp3 nacht domain. Inhibits il-1β, il-18 and il-1α production (ic50 values are 7.2, 10.3 And 12-18 nm, respectively). Selective for nlrp3 over nlrc4 inflammasome and toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione s-transferase omega 1 inhibitor. Orally bioavailable.