Gap19, Cx43 Hemichannel Blocker, Each

Details:

Gap19 is a selective connexin 43 (cx43) hemichannel blocker; has no effect on gap junction coupling or panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered atp release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.