Gsk 137647, Potent And Selective Ffa4 (Gpr120) Agonist, Each

Details:

Gsk 137647 is a potent and selective ffa4 (gpr120) agonist (pec50 values are 6.3, 6.2 And 6.1 At the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including ffa1, ffa2 and ffa3. Enhances glucose-stimulated insulin secretion in min6 cells. Induces intracellular calcium accumulation in u2os cells; this activity is inhibited by ah 7614 (cat. No. 5256).